Pro‐neurotrophins, sortilin, and nociception
نویسندگان
چکیده
منابع مشابه
Pro-neurotrophins, sortilin, and nociception
Nerve growth factor (NGF) signaling is important in the development and functional maintenance of nociceptors, but it also plays a central role in initiating and sustaining heat and mechanical hyperalgesia following inflammation. NGF signaling in pain has traditionally been thought of as primarily engaging the classic high-affinity receptor tyrosine kinase receptor TrkA to initiate sensitizatio...
متن کاملIncreased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2, and NTSR3 also called sortilin). Pharmacological approaches and generation of NTSR1 and NTSR2-deficient mice allowed to determine the NT-induced antipsychotic like behavior, the inhibitory of weak fear memory and the nociceptive signaling in a rat formalin tonic pain model...
متن کاملProneurotrophins, seizures, and neuronal apoptosis.
Neurons respond to numerous factors in their environment that influence their survival and function during development and in the mature brain. Among these factors, the neurotrophins have been shown to support neuronal survival and function, acting primarily through the Trk family of receptor tyrosine kinases. However, recent studies have established that the uncleaved neurotrophin precursors, ...
متن کاملNRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death.
Proneurotrophins mediate neuronal apoptosis using a dual receptor complex of sortilin and p75(NTR). Although p75(NTR) is highly expressed on the plasma membrane and accessible to proneurotrophin ligands, sortilin is primarily localized to intracellular membranes, limiting the formation of a cell surface co-receptor complex. Here, we show that the mammalian p75(NTR) homologue NRH2 critically reg...
متن کاملSortilin and atherosclerosis
The complexity and intricacy of nature has recently been illustrated with the role of sortilin in atherosclerosis. Sortilin, a VPS10p sorting receptor initially identified in human brain tissue, suddenly gained much attention from the cardiovascular community as unbiased genome-wide association studies (GWASs) repeatedly demonstrated that single nucleotide polymorphisms (SNPs) at the 1p13.3 loc...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2014
ISSN: 0953-816X,1460-9568
DOI: 10.1111/ejn.12466